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Article

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.

Journal of molecular and cellular cardiology - 1 Nov 2015

Basheer Wassim A, Harris Brett S, Mentrup Heather L, Abreha Measho, Thames Elizabeth L, Lea Jessica B, Swing Deborah A, Copeland Neal G, Jenkins Nancy A, Price Robert L, Matesic Lydia E

Abstract excerpt

Gap junctions (GJ) are intercellular channels composed of connexin subunits that play a critical role in a diverse number of cellular processes in all tissue types. In the heart, GJs mediate electrical coupling between cardiomyocytes and display mislocalization and/or downregulation in cardiac disease (a process known as GJ remodeling), producing an arrhythmogenic substrate. The main constituent of GJs in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26386426
DOI: 10.1016/j.yjmcc.2015.09.004
PMCID: PMC4641030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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