Article

Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression

2019-09-05

Abstract excerpt

ETS domain-containing protein-1 (ELK1) is a transcriptional repressor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ1) and are increased in the alveolar epithelium in Idiopathic Pulmonary Fibrosis (IPF). IPF is a disease associated with ageing and therefore we hypothesised that aged animals lacking Elk1 globally would develop...

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Literature Corpus work: 163819fb-00c3-5fd0-a81b-7a4559fe6910
DOI: 10.1101/755694

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