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Article

The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2020

Matesic Lydia E, Freeburg Lisa A, Snyder Laura B, Duncan Lauren-Ashley, Moore Amber, Perreault Paige E, Zellars Kia N, Goldsmith Edie C, Spinale Francis G

Abstract excerpt

Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure (HF) with a preserved ejection fraction (EF; HFpEF). We hypothesized that overexpression (O/E) of WWP1 in the heart would cause LVH as well as functional and structural changes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32822210
DOI: 10.1152/ajpheart.00620.2019
PMCID: PMC7717125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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