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Article

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.

Circulation research - 26 Sept 2014

Gupta Manish K, Gulick James, Liu Ruijie, Wang Xuejun, Molkentin Jeffery D, Robbins Jeffrey

Abstract excerpt

RATIONALE: Impairment of proteasomal function is pathogenic in several cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates. The ubiquitin proteasome system (UPS) is primarily responsible for cellular protein degradation, and although the role of ubiquitination in this process is well studied, the function of...

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Identifiers

PMID: 25097219
DOI: 10.1161/CIRCRESAHA.115.304760
PMCID: PMC4180728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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