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Article

Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.

The Journal of clinical investigation - 1 Jan 2011

Ceccaldi Raphael, Briot Delphine, Larghero Jérôme, Vasquez Nadia, Dubois d'Enghien Catherine, Chamousset Delphine, Noguera Maria-Elena, Waisfisz Quinten, Hermine Olivier, Pondarre Corinne, Leblanc Thierry, Gluckman Eliane, Joenje Hans, Stoppa-Lyonnet Dominique, Socié Gérard, Soulier Jean

Abstract excerpt

DNA damage checkpoints in the cell cycle may be important barriers against cancer progression in human cells. Fanconi anemia (FA) is an inherited DNA instability disorder that is associated with bone marrow failure and a strong predisposition to cancer. Although FA cells experience constitutive c...

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Identifiers

PMID: 21183791
DOI: 10.1172/JCI43836
PMCID: PMC3007150

Genes

ATR
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21183791-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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