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Article

Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.

CNS neuroscience & therapeutics - 1 Nov 2015

Levran Orna, Peles Einat, Randesi Matthew, Correa da Rosa Joel, Ott Jurg, Rotrosen John, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

AIM: Drug addiction is characterized, in part, by deregulation of synaptic plasticity in circuits involved in reward, stress, cue learning, and memory. This study was designed to assess whether 185 variants in 32 genes central to synaptic plasticity and signal transduction contribute to vulnerability to develop heroin and/or cocaine addiction. METHODS: Analyses were conducted in a sample of 1860 subjects divided...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26384852
DOI: 10.1111/cns.12450
PMCID: PMC4619135

Genes

MPDZ
NFKB1
NTSR1
EPHA4
EPHA6
FOSL2
MAPK3
MBP
NTRK2
PRKCE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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