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Article

Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry.

Progress in neuro-psychopharmacology & biological psychiatry - 4 Jan 2016

Levran Orna, Peles Einat, Randesi Matthew, Correa da Rosa Joel, Ott Jurg, Rotrosen John, Adelson Miriam, Kreek Mary Jeanne

Abstract excerpt

BACKGROUND: Drug addiction, a leading health problem, is a chronic brain disease with a significant genetic component. Animal models and clinical studies established the involvement of glutamate and GABA neurotransmission in drug addiction. This study was designed to assess if 258 variants in 27 genes of these systems contribute to the vulnerability to develop drug addiction. METHODS: Four independent analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26277529
DOI: 10.1016/j.pnpbp.2015.08.003
PMCID: PMC4564302

Genes

GAD1
DBI
GABRB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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