Article
Detection and quantification of rare mutations with massively parallel sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2011
Kinde Isaac, Wu Jian, Papadopoulos Nick, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Although massively parallel sequencing instruments are in principle well suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially...
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