Article
Induction of M2 regulatory macrophages through the β2-adrenergic receptor with protection during endotoxemia and acute lung injury.
Journal of innate immunity - 1 Jan 2014
Grailer Jamison J, Haggadone Mikel D, Sarma J Vidya, Zetoune Firas S, Ward Peter A
Abstract excerpt
The main drivers of acute inflammation are macrophages, which are known to have receptors for catecholamines. Based on their function, macrophages are broadly categorized as having either M1 (proinflammatory) or M2 phenotypes (anti-inflammatory). In this study, we investigated catecholamine-induced alterations in the phenotype of activated macrophages. In the presence of lipopolysaccharide (LPS), mouse peritoneal...
Topics
- Acute Lung Injury
- Animals
- Catecholamines
- Cell Differentiation
- Cells, Cultured
- Disease Models, Animal
- Endotoxemia
- Epinephrine
- Humans
- Lipopolysaccharides
- Lymphocyte Activation
- Macrophage Activation
- Macrophages, Peritoneal