Article
The transition of M-CSF-derived human macrophages to a growth-promoting phenotype.
Blood advances - 10 Nov 2020
Hamidzadeh Kajal, Belew Ashton T, El-Sayed Najib M, Mosser David M
Abstract excerpt
Stimulated macrophages are potent producers of inflammatory mediators. This activity is highly regulated, in part, by resolving molecules to prevent tissue damage. In this study, we demonstrate that inflammation induced by Toll-like receptor stimulation is followed by the upregulation of receptors for adenosine (Ado) and prostaglandin E2 (PGE2), which help terminate macrophage activation and initiate tissue...
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