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Article

Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA.

Cells - 11 Aug 2022

Halimani Noreen, Nesterchuk Mikhail, Andreichenko Irina N, Tsitrina Alexandra A, Elchaninov Andrey, Lokhonina Anastasia, Fatkhudinov Timur, Dashenkova Nataliya O, Brezgina Vera, Zatsepin Timofei S, Mikaelyan Arsen S, Kotelevtsev Yuri V

Abstract excerpt

Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect. We describe an alternative approach based on small interfering RNA (siRNA) knockdown of selected molecular cues of macrophage polarization, namely EGR2, IRF3, IRF5, and TLR4 in...

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Identifiers

PMID: 36010574
DOI: 10.3390/cells11162498
PMCID: PMC9406732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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