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Spleen-derived macrophages are readily polarized into classically activated (M1) or alternatively activated (M2) states.

Immunobiology - 1 Oct 2014

Mulder Rylend, Banete Andra, Basta Sameh

Abstract excerpt

Bone marrow derived macrophages (BM-MΦ) that differentiate from precursor cells can be polarized into classically activated pro-inflammatory (M1) or alternatively activated (M2) states depending upon the cytokine microenvironment. We questioned whether tissue MΦ, such as spleen-derived MΦ (Sp-MΦ), have the ability to differentiate into M1 or M2 cells. We show in response to activation with IFN-gamma (IFN-γ) and...

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Identifiers

PMID: 24954891
DOI: 10.1016/j.imbio.2014.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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