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Article

Identifying functional microRNAs in macrophages with polarized phenotypes.

The Journal of biological chemistry - 22 Jun 2012

Graff Joel W, Dickson Anne M, Clay Gwendolyn, McCaffrey Anton P, Wilson Mary E

Abstract excerpt

Macrophages respond to external stimuli with rapid changes in expression of many genes. Different combinations of external stimuli lead to distinct polarized activation patterns, resulting in a spectrum of possible macrophage activation phenotypes. MicroRNAs (miRNAs) are small, noncoding RNAs that can repress the expression of many target genes. We hypothesized that miRNAs play a role in macrophage polarization....

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Identifiers

PMID: 22549785
DOI: 10.1074/jbc.M111.327031
PMCID: PMC3381144

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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