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Article

EGFR and KRAS Mutations in ALK-Positive Lung Adenocarcinomas: Biological and Clinical Effect.

Clinical lung cancer - 1 Jan 2016

Sahnane Nora, Frattini Milo, Bernasconi Barbara, Zappa Francesco, Schiavone Giovanna, Wannesson Luciano, Antonelli Paola, Balzarini Piera, Sessa Fausto, Mazzucchelli Luca, Tibiletti Maria Grazia, Martin Vittoria

Abstract excerpt

INTRODUCTION: In lung adenocarcinoma (ADC), anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements are mutually exclusive with epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. However, the existence of double-positive (DP) patients have been sporadically described. We identified DP cases in therapy-naive ALK-rearranged ADC and characterized the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26381283
DOI: 10.1016/j.cllc.2015.08.001

Genes

EGFR
KRAS
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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