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Article

Rare discrepancies in a driver gene alteration within histologically heterogeneous primary lung cancers.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2015

Zhong Wen-zhao, Su Jian, Xu Fang-ping, Zhai Hao-ran, Zhang Xu-chao, Yang Xue-ning, Chen Zhi-yong, Chen Zhi-hong, Li Wei, Dong Song, Zhou Qing, Yang Jin-ji, Liu Yan-hui, Wu Yi-long

Abstract excerpt

OBJECTIVES: Most lung adenocarcinomas consist of mixtures of histological subtypes harboring different frequencies of driver gene mutations. However, little is known about intratumoral heterogeneity(ITH) within histologically heterogeneous primary lung cancers. Investigating key driver genes in respective morphological pattern is crucial to personalized treatment. METHODS: Morphologically different areas within...

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Identifiers

PMID: 26391021
DOI: 10.1016/j.lungcan.2015.09.007

Genes

ALK
EGFR
EML4
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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