Article
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcome in resected non-small cell lung cancer patients.
American journal of clinical oncology - 1 Aug 2014
Ragusa Mark, Vannucci Jacopo, Ludovini Vienna, Bianconi Fortunato, Treggiari Stefano, Tofanetti Francesca R, Flacco Antonella, Colella Renato, Sidoni Angelo, Crinò Lucio, Puma Francesco
Abstract excerpt
OBJECTIVES: Surgery yields best results for non-small cell lung cancer (NSCLC) patients. Epidermal growth factor receptor (EGFR) and its downstream factor Kirsten rat sarcoma viral oncogene homolog (KRAS) are variably mutated in NSCLC. Such mutations predict clinical response to tyrosine kinase i...
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