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Article

Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2012

McLeer-Florin Anne, Moro-Sibilot Denis, Melis Adrien, Salameire Dimitri, Lefebvre Christine, Ceccaldi Françoise, de Fraipont Florence, Brambilla Elisabeth, Lantuejoul Sylvie

Abstract excerpt

INTRODUCTION: In 2011, the French National Cancer Institute recommended ALK-fluorescence in situ hybridization (FISH) testing in all EGFR/KRAS-negative adenocarcinomas by all the hospital molecular genetics platforms of cancers; however, this technique remains time and cost consuming and not suitable for a large-scale screening, in contrast to immunohistochemistry (IHC). METHODS: To evaluate IHC as a prescreening...

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Identifiers

PMID: 22071784
DOI: 10.1097/JTO.0b013e3182381535

Genes

ALK
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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