Nonsquamous, Non-Small-Cell Lung Cancer Patients Who Carry a Double Mutation of EGFR, EML4-ALK or KRAS: Frequency, Clinical-Pathological Characteristics, and Response to Therapy.

doi:10.1016/j.cllc.2015.11.004

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Article

Nonsquamous, Non-Small-Cell Lung Cancer Patients Who Carry a Double Mutation of EGFR, EML4-ALK or KRAS: Frequency, Clinical-Pathological Characteristics, and Response to Therapy.

Clinical lung cancer - 1 Sept 2016

Ulivi Paola, Chiadini Elisa, Dazzi Claudio, Dubini Alessandra, Costantini Matteo, Medri Laura, Puccetti Maurizio, Capelli Laura, Calistri Daniele, Verlicchi Alberto, Gamboni Alessandro, Papi Maximilian, Mariotti Marita, De Luigi Nicoletta, Scarpi Emanuela, Bravaccini Sara, Turolla Gian Michele, Amadori Dino, Crinò Lucio, Delmonte Angelo

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, and echinoderm microtubule-associated protein-like 4 (EML4) anaplastic lymphoma kinase (ALK) translocation are generally considered to be mutually exclusive. However, concomitant mutations are found in a small number of patients and the effect of these on response to targeted therapy is...

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PMID: 26712101
DOI: 10.1016/j.cllc.2015.11.004

Genes

ALK
EML4
KRAS
EGFR

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