Article
Pri-miR-34b/c rs4938723 polymorphism contributes to acute lymphoblastic leukemia susceptibility in Chinese children.
Leukemia & lymphoma - 1 Jan 2016
Tong Na, Chu Haiyan, Wang Meilin, Xue Yao, Du Mulong, Lu Lingling, Zhang Heng, Wang Feng, Fang Yongjun, Li Jie, Wu Dongmei, Zhang Zhengdong, Sheng Xiaojing
Abstract excerpt
A polymorphism rs4938723 (T > C) within the promoter region of pri-miR-34b/c has been found to not only affect the expression of mature miR-34b/c but also contribute to the susceptibility to several cancer types. We designed a case-control study to evaluate the role of rs4938723 in childhood acute lymphoblastic leukemia (ALL). The rs4938723 CC genotype was significantly associated with reduced ALL risk...
Read the complete abstract on PubMed