Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.

Abstract excerpt

Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome sequencing data published for 684 cases of >7 common tumor types and >35 breeds, with rigorous quality control and breed validation. Our results indicate that canine tumor alteration landscape is tumor type-dependent, but likely breed-independent. Each tumor...

Topics

• Animals
• Biomarkers, Tumor
• Databases, Genetic
• Dog Diseases
• Dogs
• Humans
• Mutation
• Neoplasms
• Reproducibility of Results
• Tumor Suppressor Protein p53
• Whole Genome Sequencing