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Article

Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival.

Scientific reports - 8 Feb 2025

van der Heiden Anna Darlene, Pensch Raphaela, Agger Sophie, Gardner Heather L, Hendricks William, Zismann Victoria, Wong Shukmei, Briones Natalia, Turner Bryce, Forsberg-Nilsson Karin, London Cheryl, Lindblad-Toh Kerstin, Arendt Maja Louise

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematopoietic neoplasm that affects humans as well as dogs. While previous studies on canine DLBCL (cDLBCL) have significantly advanced our understanding of the disease, the majority of this research has relied on whole-exome sequencing, which is limited in its ability to detect copy number aberrations and other genomic changes beyond coding regions....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 39922874
DOI: 10.1038/s41598-025-89245-0
PMCID: PMC11807134

Genes

H3C8
DDX3X
GNAZ
IGL
KIT
MYC
POT1
PRAME
RAB36
RSPH14
SETD2
TBL1XR1
TP53
TRAF3
ZNF280B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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