Shared and distinct genetic features in human and canine B-cell lymphomas

Abstract excerpt

<h4>ABSTRACT</h4> Animal models of human cancers are an important tool for the development and preclinical evaluation of therapeutics. Canine B-cell lymphoma (cBCL) is an appealing model for human mature B-cell neoplasms due to the high sequence similarity in cancer genes to humans and inactive telomerase in adult tissues. We performed targeted sequencing on 86 canine patients from the Canine Comparative Oncology...

Topics

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• Germinal Center
• Immunoglobulin Heavy Chains
• Interferon Regulatory Factors
• Lymph Nodes
• Lymphoma, B-Cell
• Lymphoma, Large B-Cell, Diffuse
• NF-kappa B
• Proto-Oncogene Proteins c-bcl-6

Identifiers and source

Literature Corpus work

14e4bf9a-edd0-58f3-8851-d8fb4df13721

DOI

10.1101/2021.10.14.464277