GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.

doi:10.1523/JNEUROSCI.0041-15.2015

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GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Sept 2015

Babwah Andy V, Navarro Víctor M, Ahow Maryse, Pampillo Macarena, Nash Connor, Fayazi Mehri, Calder Michele, Elbert Adrienne, Urbanski Henryk F, Wettschureck Nina, Offermanns Stefan, Carroll Rona S, Bhattacharya Moshmi, Tobet Stuart A, Kaiser Ursula B

Abstract excerpt

The gonadotropin-releasing hormone (GnRH) is the master regulator of fertility and kisspeptin (KP) is a potent trigger of GnRH secretion from GnRH neurons. KP signals via KISS1R, a Gαq/11-coupled receptor, and mice bearing a global deletion of Kiss1r (Kiss1r(-/-)) or a GnRH neuron-specific deletion of Kiss1r (Kiss1r(d/d)) display hypogonadotropic hypogonadism and infertility. KISS1R also signals via β-arrestin,...

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PMID: 26377475
DOI: 10.1523/JNEUROSCI.0041-15.2015
PMCID: PMC4571609

Genes

KISS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.PMID 26377475Read ↗

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