GPR54 Regulates ERK1/2 Activity and Hypothalamic Gene Expression in a Gαq/11 and β-Arrestin-Dependent Manner

Abstract excerpt

G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation. Kp and GPR54 are established regulators of the hypothalamic-pituitary-gonadal (HPG) axis and loss-of-function mutations in GPR54 are associated with an absence of puberty and hypogonadotropic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hypothalamic control of reproductive hormones
• Share to Neuropeptides and Animal Physiology
• Share to Receptor Mechanisms and Signaling