Article
Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice.
Endocrinology - 1 Mar 2010
Wu Sheng, Wilson Michael D, Busby Ellen R, Isaac Emma R, Sherwood Nancy M
Abstract excerpt
Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor. To determine whether the GnRH receptor is critical at all stages of reproduction and whether this receptor ha...
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