Article
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
Scientific reports - 12 Jan 2016
León Silvia, Barroso Alexia, Vázquez María J, García-Galiano David, Manfredi-Lozano María, Ruiz-Pino Francisco, Heras Violeta, Romero-Ruiz Antonio, Roa Juan, Schutz Günther, Kirilov Milen, Gaytan Francisco, Pinilla Leonor, Tena-Sempere Manuel
Abstract excerpt
Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable. To dissect out direct vs. indirect effects of kisspeptins on GnRH neurons in vivo, we report herein the detailed reproductive/gonadotropic characterization of a Gpr54 null mouse...
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