Article
Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice.
The Journal of reproduction and development - 20 Aug 2020
Ikegami Kana, Goto Teppei, Nakamura Sho, Watanabe Youki, Sugimoto Arisa, Majarune Sutisa, Horihata Kei, Nagae Mayuko, Tomikawa Junko, Imamura Takuya, Sanbo Makoto, Hirabayashi Masumi, Inoue Naoko, Maeda Kei-Ichiro, Tsukamura Hiroko, Uenoyama Yoshihisa
Abstract excerpt
The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the fundamental role of hypothalamic kisspeptin neurons in regulating mammalian reproduction. We generated Kiss1-floxed mice and hypothalamic kisspeptin neuron-specific...
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