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Article

Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation

31 Mar 2017

Abstract excerpt

Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a modest benefit in preventing VILI because they cannot impede alveolar overdistension and concomitant...

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PMID: 28363030
DOI: 10.1165/rcmb.2016-0404oc

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