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Activating Transcription Factor 3 Confers Protection against Ventilator-induced Lung Injury

25 Jun 2010

Abstract excerpt

RATIONALE: Ventilator-induced lung injury (VILI) significantly contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury. Understanding the molecular basis for response to cyclic stretch (CS) and its derangement during high-volume ventilation is of high priority. OBJECTIVES: To identify specific molecular regulators involved in the development of...

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PMID: 20413626
DOI: 10.1164/rccm.200906-0925oc

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