Article
DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors.
Cancer cell - 14 Sept 2015
Mazor Tali, Pankov Aleksandr, Johnson Brett E, Hong Chibo, Hamilton Emily G, Bell Robert J A, Smirnov Ivan V, Reis Gerald F, Phillips Joanna J, Barnes Michael J, Idbaih Ahmed, Alentorn Agusti, Kloezeman Jenneke J, Lamfers Martine L M, Bollen Andrew W, Taylor Barry S, Molinaro Annette M, Olshen Adam B, Chang Susan M, Song Jun S, Costello Joseph F
Abstract excerpt
The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and sensitive to the microenvironment, prompting the question whether epigenetic information can similarly be used to discover tumor phylogeny. We examined the spatial and temporal dynamics of DNA methylation in a cohort of low-grade...
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