Article

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

2024-03-07

Abstract excerpt

1 To study the evolutionary processes that drive malignant progression of IDH-mutant astrocytomas, we performed multi-omics on a large cohort of matched initial and recurrent tumor samples. The overlay of genetic, epigenetic, transcriptomic and proteomic data, combined with single-cell analysis, have identified overlapping features associated with malignant progression. These features are derived from three molecu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8147f353-613d-5433-a31e-2e3b73a70d5e
DOI: 10.1101/2024.03.05.583306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cyclingDOI 10.1101/2024.03.05.583306Read

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cyclingSemantic proximity Read

Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma.Semantic proximity Read

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cyclingSemantic proximity Read

Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytomaSemantic proximity Read

Acquired genetic and cell-state changes in IDH-mutant glioma progression.Semantic proximity Read

Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomasSemantic proximity Read

Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.Semantic proximity Read

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas.Semantic proximity Read

TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas.Semantic proximity Read

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.Semantic proximity Read

Single-nucleus multiomics unveils malignant cellular states, regulatory architectures and microenvironmental reorganization across the G-CIMP epigenomic transition in IDH-mutant gliomaSemantic proximity Read

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.Semantic proximity Read