Article

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

2024-03-21

Abstract excerpt

<title>Abstract</title> <p>To study the evolutionary processes that drive malignant progression of IDH-mutant astrocytomas, we performed multi-omics on a large cohort of matched initial and recurrent tumor samples. The overlay of genetic, epigenetic, transcriptomic and proteomic data, combined with single-cell analysis, have identified overlapping features associated with malignant progression. These features are...

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Literature Corpus work: 6a6fa522-f6f9-5d99-bd15-ffe0d450ee53
DOI: 10.21203/rs.3.rs-3996609/v1

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