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Article

The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans.

eLife - 15 Sept 2015

Koelle Katia, Rasmussen David A

Abstract excerpt

Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mutation load. This mutation load has the potential to shape patterns of adaptive evolution via genetic linkage to beneficial mutations. Here, we examine the effect of deleterious mutations on patterns of influenza A subtype H3N2's antigenic evolution in humans. By first analyzing simple models of influenza that...

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Identifiers

PMID: 26371556
DOI: 10.7554/eLife.07361
PMCID: PMC4611170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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