Article
The roles of competition and mutation in shaping antigenic and genetic diversity in influenza.
PLoS pathogens - 1 Jan 2013
Zinder Daniel, Bedford Trevor, Gupta Sunetra, Pascual Mercedes
Abstract excerpt
Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and genetics. A major open question is why the virus population is globally dominated by a single and very recently diverged (2-8 years) lineage. Classically, this has been modeled by limiting the generation of new successful antigenic variants, such that only...
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