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Article

Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans.

Science (New York, N.Y.) - 22 Dec 2006

Koelle Katia, Cobey Sarah, Grenfell Bryan, Pascual Mercedes

Abstract excerpt

Human influenza A (subtype H3N2) is characterized genetically by the limited standing diversity of its hemagglutinin and antigenically by clusters that emerge and replace each other within 2 to 8 years. By introducing an epidemiological model that allows for differences between the genetic and antigenic properties of the virus's hemagglutinin, we show that these patterns can arise from cluster-specific immunity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17185596
DOI: 10.1126/science.1132745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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