Article

Cardiac Specific Overexpression of Adenylyl Cyclase 8 Reprograms the Mouse Sinoatrial Node Transcriptome

2023-09-28

Abstract excerpt

A coupled-clock system intrinsic to sinoatrial node (SAN) pacemaker cells that regulates the rate and rhythm of spontaneous action potential firing, is activated by Ca 2+ /calmodulin-stimulated Adenylyl Cyclase (AC) types 8 and 1. Our previous work in mice with cardiac specific overexpression of human AC8 gene (TGAC8) discovered that compared to its wild-type (WT) littermates, the heart rate (HR) of TGAC8 is elev...

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Literature Corpus work: fbfc4e52-2af0-5d0f-843c-7eff94e8b049
DOI: 10.1101/2023.09.26.559627

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Cardiac Specific Overexpression of Adenylyl Cyclase 8 Reprograms the Mouse Sinoatrial Node TranscriptomeDOI 10.1101/2023.09.26.559627Read

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