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Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge.

Antimicrobial agents and chemotherapy - 1 Dec 2015

Kriegeskorte Andre, Lorè Nicola Ivan, Bragonzi Alessandra, Riva Camilla, Kelkenberg Marco, Becker Karsten, Proctor Richard A, Peters Georg, Kahl Barbara C

Abstract excerpt

Trimethoprim-sulfamethoxazole (SXT) is a possible alternative for the treatment of community- and hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) due to the susceptibility of most MRSA strains to the drug. However, after long-term treatment with SXT, thymidine-dependent (TD) SXT-resistant small-colony variants (SCVs) emerge. In TD-SCVs, mutations of thymidylate synthase ([TS] thyA) occur....

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Identifiers

PMID: 26369968
DOI: 10.1128/AAC.00742-15
PMCID: PMC4649163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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