Article
Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus.
International journal of medical microbiology : IJMM - 1 Jul 2007
Besier Silke, Ludwig Albrecht, Ohlsen Knut, Brade Volker, Wichelhaus Thomas A
Abstract excerpt
Thymidine-auxotrophic small colony variants (SCVs) of Staphylococcus aureus are frequently isolated from the chronically infected airways of patients suffering from cystic fibrosis. To date, little is known regarding the molecular mechanisms leading to the formation of this special phenotype, but the auxotrophism for thymidine suggests that impaired thymidine metabolism might play a major role. Sequence analysis...
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