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Article

Thymidine-auxotrophic Staphylococcus aureus small-colony variant bacteremia in a patient with cystic fibrosis.

Pediatric pulmonology - 1 Jun 2020

de Souza Dilair C, Cogo Laura L, Palmeiro Jussara K, Dalla-Costa Libera M, de Oliveira Tomaz Ana P, Riedi Carlos A, Rosario Filho Nelson A

Abstract excerpt

BACKGROUND: Small-colony variants (SCVs) are a morphologic subtype of Staphylococcus aureus that may occur through several mechanisms including auxotrophism for thymidine, hemin, or menadione. Auxotrophic SCV for thymidine fail to synthesize DNA specifically because of mutations in the thymidylate synthase gene. We isolated S. aureus thymidine-dependent SCVs (TD-SCV) from blood and respiratory samples of a...

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PMID: 32176841
DOI: 10.1002/ppul.24730

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