Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates.

Antimicrobial agents and chemotherapy - 1 Jun 2008

Besier Silke, Zander Johannes, Kahl Barbara C, Kraiczy Peter, Brade Volker, Wichelhaus Thomas A

Abstract excerpt

Thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus can be isolated from the airway secretions of patients suffering from cystic fibrosis (CF) and are implicated in persistent and treatment-resistant infections. These characteristics, as well as the variety of mutations in the thymidylate synthase-encoding thyA gene which are responsible for thymidine dependency, suggest that these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Staphylococcal Infections

Share to Staphylococcus aureus

Share to Thymidine

Source

Open in PubMed Open full text

Identifiers

PMID: 18378706
DOI: 10.1128/AAC.01395-07
PMCID: PMC2415776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates.PMID 18378706Read ↗

Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil.Semantic proximity Read ↗

Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus.Semantic proximity Read ↗

Thymidine-auxotrophic Staphylococcus aureus small-colony variant bacteremia in a patient with cystic fibrosis.Semantic proximity Read ↗

In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus.Semantic proximity Read ↗

Staphylococcus aureus Small-Colony Variants from Airways of Adult Cystic Fibrosis Patients as Precursors of Adaptive Antibiotic-Resistant MutationsSemantic proximity Read ↗

Small colony variants of Staphylococcus aureus--review.Semantic proximity Read ↗

Prevalence and genetic diversity of Staphylococcus aureus small-colony variants in cystic fibrosis patients.Semantic proximity Read ↗

Inactivation of thyA in Staphylococcus aureus Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene ExpressionSemantic proximity Read ↗

Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase.Semantic proximity Read ↗

Prevalence and clinical significance of Staphylococcus aureus small-colony variants in cystic fibrosis lung disease.Semantic proximity Read ↗

Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy.Semantic proximity Read ↗

Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.