Article
Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data.
The Journal of antimicrobial chemotherapy - 1 Jul 2013
Garcia Laetitia G, Lemaire Sandrine, Kahl Barbara C, Becker Karsten, Proctor Richard A, Denis Olivier, Tulkens Paul M, Van Bambeke Françoise
Abstract excerpt
The pathogen Staphylococcus aureus uses various strategies for persisting in the host, among which switching to a small-colony variant (SCV) phenotype is of particular biological and therapeutic significance. Phenotypically, SCVs are characterized by a slow growth rate, atypical colony morphology and unusual biochemical features, constituting a real challenge for identification by the clinical microbiology...
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