Article
In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus.
Journal of bacteriology - 1 Feb 2008
Chatterjee Indranil, Kriegeskorte Andre, Fischer Andreas, Deiwick Susanne, Theimann Nadine, Proctor Richard A, Peters Georg, Herrmann Mathias, Kahl Barbara C
Abstract excerpt
Trimethoprim-sulfamethoxazole (SXT)-resistant Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs) are frequently isolated from the airways of cystic fibrosis (CF) patients, often in combination with isogenic normal strains if patients were treated with SXT for extended periods. As SXT inhibits the synthesis of tetrahydrofolic acid, which acts as a cofactor for thymidylate synthase (thyA),...
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