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Integrative omics analysis reveals insights into small colony variants of Staphylococcus aureus induced by sulfamethoxazole-trimethoprim.

BMC microbiology - 14 Jun 2024

Zhou Jingwen, He Chunyan, Yang Han, Shu Wen, Liu Qingzhong

Abstract excerpt

BACKGROUND: Long-term treatment with trimethoprim-sulfamethoxazole (SXT) can lead to the formation of small-colony variants (SCVs) of Staphylococcus aureus. However, the mechanism behind SCVs formation remains poorly understood. In this study, we explored the phenotype and omics-based characterization of S. aureus SCVs induced by SXT and shed light on the potential causes of SCV formation. METHODS: Stable SCVs...

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Anti-Bacterial Agents
Genomics
Metabolomics
Microbial Sensitivity Tests
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Staphylococcus aureus

Trimethoprim, Sulfamethoxazole Drug Combination

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PMID: 38877418
DOI: 10.1186/s12866-024-03364-8
PMCID: PMC11179224

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