Article
A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression.
PloS one - 1 Jan 2015
Makino Yasukazu, Konoshita Tadashi, Omori Atsuhito, Maegawa Nobuhiro, Nakaya Takahiro, Ichikawa Mai, Yamamoto Katsushi, Wakahara Shigeyuki, Ishizuka Tamotsu, Onoe Tamehito, Nakamura Hiroyuki
Abstract excerpt
BACKGROUND: The high heritability of plasma renin activity was confirmed in recent investigations. A variation located near the strong enhancer of the human renin gene (REN), C-5312T, has been shown to have different transcription activity levels depending on its allele: the 5312T allele shows transcription levels that are 45% greater than those of the 5312C allele. The purpose of this study was to confirm the...
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