Article
Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2007
Moore Niamh, Dicker Patrick, O'Brien John K, Stojanovic Milos, Conroy Ronán M, Treumann Achim, O'Brien Eoin T, Fitzgerald Desmond, Shields Denis, Stanton Alice V
Abstract excerpt
Renin catalyzes the rate-limiting step of the renin-angiotensin system. A T allele variant at position -5312 within a distal enhancer region has been reported to increase in vitro renin gene transcription. Among 387 White bank employees, ambulatory blood pressures were higher in 133 -5312T allele carriers than in 254 CC homozygotes-mean differences [99% confidence interval] between carriers and homozygotes for...
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