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Article

GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.

Nature communications - 14 Sept 2015

Xiao Xiang, Shi Xiaomin, Fan Yihui, Zhang Xiaolong, Wu Minhao, Lan Peixiang, Minze Laurie, Fu Yang-Xin, Ghobrial Rafik M, Liu Wentao, Li Xian Chang

Abstract excerpt

Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory molecule with diverse effects on effector T cells and regulatory T cells (Tregs), but the underlying mechanism remains poorly defined. Here we demonstrate that GITR ligation subverts the induction of Foxp3(+) Tregs and directs the activated CD4(+) T cells to Th9 cells. Such GITR-mediated iTreg to Th9 induction enhances anti-tumour immunity in...

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PMID: 26365427
DOI: 10.1038/ncomms9266
PMCID: PMC4570275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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