Article
Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation.
The Journal of biological chemistry - 4 May 2012
Jash Arijita, Sahoo Anupama, Kim Gi-Cheon, Chae Chang-Suk, Hwang Ji-Sun, Kim Jung-Eun, Im Sin-Hyeog
Abstract excerpt
IL-9 regulates diverse inflammatory immune responses. Although the functional importance of IL-9 has been investigated in various pathophysiological conditions, molecular mechanisms by which TCR stimulation induced IL-9 gene expression are still unclear. In this study, we investigated the functional importance of the NFAT1 and NF-κB (p65) in IL-9 gene transcription in CD4(+) T cells. In vivo binding of NFAT1 and...
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