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Article

Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice.

Atherosclerosis - 1 Nov 2015

Tiniakou Ioanna, Kanaki Zoi, Georgopoulos Spiros, Chroni Angeliki, Van Eck Miranda, Fotakis Panagiotis, Zannis Vassilis I, Kardassis Dimitris

Abstract excerpt

OBJECTIVE: Mutations in human apolipoprotein A-I (apoA-I) are associated with low high-density lipoprotein (HDL) cholesterol levels and pathological conditions such as premature atherosclerosis and amyloidosis. In this study we functionally characterized two natural human apoA-I mutations, L141RPisa and L159RFIN, in vivo. METHODS: We generated transgenic mice expressing either wild-type (WT) or the two mutant...

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PMID: 26363436
DOI: 10.1016/j.atherosclerosis.2015.08.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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