Article
LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.
Biochemistry - 18 Sept 2007
Koukos Georgios, Chroni Angeliki, Duka Adelina, Kardassis Dimitris, Zannis Vassilis I
Abstract excerpt
To explain the etiology and find a mode of therapy of genetically determined low levels of high-density lipoprotein (HDL), we have generated recombinant adenoviruses expressing apolipoprotein A-I (apoA-I)(Leu141Arg)Pisa and apoA-I(Leu159Arg)FIN and studied their properties in vitro and in vivo. Both mutants were secreted efficiently from cells but had diminished capacity to activate lecithin/cholesterol...
Topics
- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Transporters
- Adenoviridae Infections
- Animals
- Apolipoprotein A-I
- Arginine
- Cell Line, Tumor
- Cholesterol
- Enzyme Activation
- Gene Expression Regulation
- Humans
- Leucine
- Lipids