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Article

FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.

Current topics in developmental biology - 1 Jan 2018

Davy Philip M C, Allsopp Richard C, Donlon Timothy A, Morris Brian J, Willcox Donald Craig, Willcox Bradley J

Abstract excerpt

Aging is a complex, multifactorial process with significant plasticity. While several biological pathways appear to influence aging, few genes have been identified that are both evolutionarily conserved and have a strong impact on aging and age-related phenotypes. The FoxO3 gene (FOXO3), and its homologs in model organisms, appears especially important, forming a key gene in the insulin/insulin-like growth...

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Identifiers

PMID: 29433738
DOI: 10.1016/bs.ctdb.2017.10.001
PMCID: PMC7295567

Genes

FOXO3

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